The mature nervous system such as

During nerve development, neurotrophins help nerve cells decide if they are going to live or die. Neurotrophins are small proteins secreted in the nervous system at extremely low concentrations. Low levels of a neurotrophin are needed to keep nerve cells alive. However, in some cases, presence of a neurotrophin can have the opposite effect, initiating cell-death. During development of the nervous system, levels of neurotrophins control unwanted nerve cells.

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The role of BDNF in epilepsy and other diseases of the mature nervous system.

Aging changes in the nervous system: MedlinePlus Medical Encyclopedia

The terminal differentiation of many developing neurons occurs after they innervate their target cells and is triggered by secreted target-derived signals that are transduced by presynaptic cognate receptors. Such retrograde signaling induces the expression of genes that are often distinctive markers of neuronal phenotype and function. However, whether long-term maintenance of neuronal phenotype requires persistent retrograde signaling remains poorly understood. Here, we used a genetic technique that spatiotemporally targets transgene expression in Drosophila to test the role of persistent BMP signaling in the maintenance of Tv phenotype.
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Neuronal phenotype in the mature nervous system is maintained by persistent retrograde bone morphogenetic protein signaling.

Heather H. Ross, Fabrisia Ambrosio, Randy D. Trumbower, Paul J. Reier, Andrea L. Behrman, Steven L.
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Sensory experience induces rapid molecular and structural changes at the synapse that have long-lasting effects on neuronal networks. These processes occur in the central as well as in the peripheral nervous system and appear to be highly conserved among species. Memory formation and consolidation is probably In the past decade several highly conserved developmental molecules Notch, Reelin, Wnt, EphB with essential roles in morphogenesis have been shown to be regulated by sensory stimuli and are involved in activity dependent changes at the synapse influencing learning and memory.
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