Because many girls and women with triple X syndrome are healthy and show no outward signs of the condition, they may remain undiagnosed all their lives, or the diagnosis may be discovered while checking other issues. Triple X syndrome may also be discovered during prenatal testing to identify other genetic disorders. If triple X syndrome is suspected based on signs and symptoms, it can be confirmed by genetic testing — chromosome analysis using a blood sample. In addition to genetic testing, genetic counseling can help you gain comprehensive information about triple X syndrome. The chromosome error that causes triple X syndrome can't be repaired, so the syndrome itself has no cure. Treatment is based on symptoms and needs.
Triplex-forming oligonucleotides TFOs have the potential to serve as gene therapeutic agents on the basis of their ability to mediate site-specific genome modification via induced recombination. Because of this sequence restriction, careful analysis is needed to identify suitable TFO target sites within or near genes of interest. We report here an examination of two key parameters which influence the efficiency of TFO-induced recombination: 1 binding affinity of the TFO for the target site and 2 the distance between the target site and the mutation to be corrected. To test the influence of binding affinity, we compared induced recombination in human cell-free extracts by a series of G-rich oligonucleotides with an identical base composition and an increasing number of mismatches in the third strand binding code. As the number of mismatches increased and, therefore, binding affinity decreased, induced recombination frequency also dropped.
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