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Somatic mutations mainly occur in the catalytic kinase domain CR3 , and the predominant mutation is p. VE which is the substitution of glutamic acid E for valine V as result of a mutation at codon of the kinase domain. To our knowledge, the vast majority of the cancers have non-germline BRAF mutations. Here we describe a case of a year-old female with a history of hairy cell leukemia HCL who presented with aphasia and forgetfulness. A follow-up Brain CT scan showed three distinct brain lesions which were found to be diagnostic of melanoma confirmed by immunohistochemistry with no evidence of a concurrent brain involvement by a B-cell neoplasm.